POZEN, Inc., a pharmaceutical company, develops therapeutic advancements for diseases with unmet medical needs. It focuses primarily on developing products for the treatment of migraine, acute, and chronic pain, as well as other pain-related indications. The company's lead product candidate is Trexima, which is being developed in collaboration with GlaxoSmithKline for the treatment of acute migraine. Trexima is GlaxoSmithKline's proposed brand name for a proprietary single tablet containing sumatriptan succinate, a 5-HT 1B/1D agonist formulated with RT Technology; and naproxen sodium, a non-steroidal anti-inflammatory drug (NSAID). The company is also developing product candidates that combine an acid inhibitor with an NSAID. POZEN has two product candidates in development that combine a proton pump inhibitor with an NSAID in a single tablet. They include PN 100, a combination of lansoprazole and naproxen; and PN 200, a combination of omeprazole and naproxen. These product candidates are intended to provide management of pain and inflammation associated with conditions, such as osteoarthritis, with fewer gastrointestinal complications compared to an NSAID taken alone. POZEN was founded in 1996 and is headquartered in Chapel Hill, North Carolina.
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