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CHINA MEDICAL TECHNOLOGIES INC (CMED)
China Medical Technologies, Inc. develops, manufactures, and markets medical devices for the treatment of solid cancers and benign tumors in the People's Republic of China. It offers In-vitro diagnostics systems, which include enhanced chemiluminescence immunoassay (ECLIA) system and fluorescent in situ hybridization (FISH) imaging analysis system and probes. The company's ECLIA system consists of ECLIA analyzer for detecting minute levels of light triggered by combining reagents with body fluid samples to produce diagnostic results; reagent kits, which are formulated to create various reactions with blood or other body fluid samples; and a data analysis system to analyze and organize the information produced form diagnostic results. It offers 62 types of reagent kits for use with the ECLIA analyzer for detecting and monitoring various types of diseases and disorders, including thyroid disorders, diabetes, hepatitis, and disorders related to reproduction and growth, SARS, Down syndrome, liver fibrosis, and various types of tumors. China Medical Technologies also offers FISH imaging analysis system and probes, which uses FISH technology for prenatal and postnatal diagnosis, and early detection and prognosis of various cancers. In addition, the company provides HIFU therapy system to treat liver, breast, and kidney tumors; solid tumors in the pelvic cavity or on bone; and tumors in the four limbs or superficial tissues. It sells its products through direct sales force and distributors. China Medical Technologies was founded in 1999 and is based in Beijing, the People's Republic of China.
NuVasive, Inc., a medical device company, focuses on the design, development, and marketing of products for the surgical treatment of spine disorders in the United States. The company's principal products include a minimally disruptive surgical platform called maximum access surgery (MAS) and classic fusion products. The MAS platform combines its product offerings, NeuroVision, a proprietary software-driven nerve avoidance system; MaXcess, a split blade-design minimally invasive surgical system; and specialized implants—that collectively minimize soft tissue disruption during spine surgery. NuVasive's classic fusion portfolio is comprised of a range of products, including spine allografts, which are human bone that has been processed and precision shaped for transplant; and spine implants such as rods, plates, and screws that are necessary for various spine surgery procedures. The company is also developing a proprietary total lateral lumbar disc replacement product and cervical disc replacement product. NuVasive sells its products through its sales agencies and representatives to hospitals. The company was founded in 1995 and is headquartered in San Diego, California.
AtriCure, Inc. engages in the development, manufacture, and sale of surgical devices designed to create precise lesions, or scars, in cardiac and soft tissues. It offers the AtriCure Isolator bipolar ablation system, which consists of an ablation sensing unit, a compact power generator that uses its proprietary software and delivers bipolar radio-frequency energy; multiple configurations of its Isolator bipolar ablation clamps; and its multifunctional bipolar Pen. The company also provides Isolator bipolar ablation clamps designed for ablation during open procedures; Isolator Synergy ablation clamps, which are designed to provide full thickness lesions in thicker and more diseased tissues; and endoscopic Isolator bipolar ablation clamps designed for use in minimally invasive procedures. In addition, it offers multifunctional bipolar Pen for the surgical ablation of cardiac tissue; and for temporary pacing, sensing, stimulating, and recording during the evaluation of cardiac arrhythmias. Further, the company sells Lumitip dissector for the dissection of soft tissues during general, thoracic, and certain other surgical procedures; and distributes cryoablation devices that use extreme cold to ablate tissue. AtriCure sells its medical devices through its direct sales force to hospitals and medical clinics primarily in the United States, as well as through distributors in Asia, Europe, Canada, the Middle East, Central America, and South America. The company was founded in 2000 and is headquartered in West Chester, Ohio.
DENTSPLY INTERNATIONAL INC (XRAY)
DENTSPLY International, Inc. and its subsidiaries engage in the design, development, manufacture, and marketing of a range of professional dental products worldwide. The company's principal dental products include dental consumables, including dental anesthetics, prophylaxis paste, dental sealants, impression materials, restorative materials, tooth whiteners, and topical fluoride; dental laboratory products which include dental prosthetics, such as artificial teeth, precious metal dental alloys, dental ceramics, and crown and bridge materials; and dental specialty products, including endodontic instruments and materials, implants, and orthodontic appliances and accessories. DENTSPLY International distributes its products through domestic and foreign distributors, dealers, and importers, as well as directly to the dental laboratory or dental professionals. DENTSPLY International is headquartered in York, Pennsylvania.
ATRION CORPORATION (ATRI)
Atrion Corporation engages in the design, development, manufacture, marketing, sale, and distribution of various products and components, primarily for the medical and health care industry worldwide. It offers ophthalmology products, which include LacriCATH product line of balloon catheters used in the treatment of nasolacrimal duct obstruction in children and adults. The company's cardiovascular products comprise MPS Myocardial Protection System that delivers essential fluids and medications to the heart during open-heart surgery; cardiac surgery vacuum relief valves; Retract-O-Tape silicone vessel loops; and Clean-Cut rotating aortic punch, used in heart bypass surgery. It also offers intravenous fluid delivery line for therapy procedures employed in anesthesia administration, intravenous feeding, intensive care, and cancer therapy. Atrion manufactures valves, tubing flanges, right angle connectors, and closures for life vests, life rafts, inflatable boats, inflatable toys, survival equipment, and other inflatable structures, as well as various one-way and two-way 'Breather' valves for use on electronics cases, munitions cases, pressure vessels, lift bags, space suits, mattresses, escape slides, and other application requiring pressure relief for use in aviation and marine safety products. In addition, the company provides contract manufacturing services for other original equipment manufacturers of medical devices, as well as warehousing and inventory management services. It offers pressure monitoring kits for use in labor and delivery procedures and various critical care applications. Further, the company owns and maintains a 22-mile high-pressure steel pipeline in north Alabama that is leased to an industrial gas producer that transports gaseous oxygen. Atrion markets its components to other equipment manufacturers; and sells finished devices to physicians, hospitals, clinics, and other treatment centers. The company is headquartered in Dallas, Texas.
MINDRAY MEDICAL INTERNATIONAL LIMITED (MR)
Mindray Medical International Limited, through its subsidiary, Shenzhen Mindray Bio-Medical Electronics Co., Ltd., engages in the development, manufacture, and marketing of medical devices. It operates through three segments: Patient Monitoring Devices, Diagnostic Laboratory Instruments, and Ultrasound Imaging Systems. The Patient Monitoring Devices segment offers approximately 20 different patient monitoring devices for use in hospital intensive care units, operating rooms, and emergency rooms. Its patient monitoring devices are used to track the physiological parameters of patients, such as heart rate, blood pressure, respiration, and temperature. This segment offers various products, including single- and multiple-parameter monitors; mobile and portable multifunction monitors; central stations that collect and display multiple patient data on a single screen; veterinary monitoring devices; anesthesia machines; and an electro-cardiogram monitoring device. The Diagnostic Laboratory Instruments segment provides data and analysis on blood, urine, and other bodily fluid samples for clinical diagnosis and treatment. This segment offers a range of semi-automated and fully-automated diagnostic laboratory instruments for laboratories, clinics, and hospitals. Its products include hematology analyzers and biochemistry analyzers; reagents; and a microplate reader and microplate washer. The Ultrasound Imaging Systems segment sells portable and mobile grayscale ultrasound imaging systems that use computer-managed sound waves to produce real time images of anatomical movement and blood flow; and a range of transducers. Mindray Medical sells its products primarily to distributors, hospitals, clinics, government agencies, original design manufacturers, and original equipment manufacturers. It operates primarily in the People's Republic of China, Europe, North America, and Asia. The company was founded in 1999 and is headquartered in Shenzhen, the People's Republic of China.
INSULET CORPORATION (PODD)
Insulet Corporation, a medical device company, engages in the development, manufacture, and marketing of insulin infusion system for people with insulin-dependent diabetes in the United States. It offers OmniPod Insulin Management System, which consists of its OmniPod disposable insulin infusion device and handheld wireless personal diabetes manager. The company's OmniPod Insulin Management System provides with a diabetes management solution, which provides lifestyle and other benefits and to expand the use of CSII therapy. Insulet Corporation was founded in 2000 and is based in Bedford, Massachusetts.
VIVUS, Inc., a pharmaceutical company, engages in the research, development, and commercialization of products to restore sexual function in women and men. Its product pipeline includes four clinical stage product candidates, including ALISTA for the treatment of female sexual arousal disorder; Testosterone-MDTS to treat hypoactive sexual desire disorder; Evamist to alleviate symptoms associated with menopause; and Avanafil, an inhibitor product candidate for the treatment of erectile dysfunction. ALISTA and Evamist are in Phase 3 trials; and Testosterone-MDTS and Avanafil are in Phase 2 trials. The company also markets MUSE, a transurethral applicator used for treating erectile dysfunction, in the United States and internationally through distribution partners. It has a development, license, and supply agreement with Tanabe Seiyaku Co., Ltd., for the development and commercialization of avanafil; and licensing agreements with Acrux Limited to develop and commercialize testosterone-MDTS and Evamist in the United States for various female health applications. VIVUS was founded by Virgil A. Place in 1991 and is headquartered in Mountain View, California.
THE ARISTOTLE CORPORATION (ARTL)
The Aristotle Corporation and its subsidiaries engage in the manufacture and distribution of educational, health, medical technology, and agricultural products. It operates in two segments, Educational and Commercial. The Educational segment primarily sells supplemental educational supplies and equipment to school districts, individual schools, teachers, and curriculum specialists, who purchase products for school and classroom use. In addition, the company sells medical technology training products, including manikins and simulation kits used for training in cardiopulmonary resuscitation and the emergency rescue, and patient care fields. The company's primary customers for its health care training products are fire and emergency medical departments, and nursing and medical schools. The Commercial segment markets agricultural supplies, and small hand tools and equipment to farmers and ranchers to assist in animal livestock and crop production. In addition, the company provides sterile sampling bags and containers. Its product line is primarily sold to the food industry, including water treatment facilities. The company distributes its products through catalogs, Web sites, and distributors to customers in the United States and internationally. The Aristotle Corporation was founded in 1986 and is headquartered in Stamford, Connecticut.
LUMINEX CORPORATION (LMNX)
Luminex Corporation engages in the design, development, manufacture, and marketing of proprietary biological testing technologies with applications throughout the life sciences industry. The company's xMAP technology enables its Luminex 100 System to simultaneously perform up to 100 bioassays on a single drop of fluid by reading biological tests that are taking place on the surface of microscopic polystyrene beads called microspheres. The xMAP technology is used in various segments of the life sciences industry, including the fields of drug discovery and development, clinical diagnostics, genetic analysis, protein analysis, and biomedical research. The company's customers include clinical diagnostic, pharmaceutical, biotechnological, and chemical companies. Luminex Corp. has an agreement with Biohit Oyj for the development and commercialisation of a diagnostic test system segment. The company was incorporated in 1995 and is based in Austin, Texas.
BAXTER INTERNATIONAL INC (BAX)
Baxter International, Inc., through its subsidiaries, assists healthcare professionals and their patients with the treatment of complex medical conditions, including cancer, hemophilia, immune disorders, kidney disease, and trauma worldwide. The company operates in three segments: Medication Delivery, BioScience, and Renal. The Medication Delivery segment provides various intravenous solutions and specialty products that are used in combination for fluid replenishment, general anesthesia, nutrition therapy, pain management, antibiotic therapy, and chemotherapy. The BioScience segment develops biopharmaceuticals, biosurgery products, vaccines and blood collection, and processing and storage products and technologies for transfusion therapies. The Renal segment develops products and provides services to treat end-stage kidney disease. The company's products are used by hospitals, clinical and medical research laboratories, blood and plasma collection centers, kidney dialysis centers, rehabilitation centers, nursing homes, doctors' offices, and by patients at home under physician supervision. It distributes its products through independent distributors, drug wholesalers acting as sales agents, and specialty pharmacy or homecare companies. Baxter International has collaborative agreements with Nektar Therapeutics to develop PEGylated therapeutic forms of blood clotting proteins for patients with hemophilia, in order to reduce the frequency of injections required to treat blood clotting disorders, such as hemophilia; and with Lipoxen Technologies, Ltd. to develop longer acting therapeutic forms of blood clotting proteins. The company was founded in 1931 and is based in Deerfield, Illinois.
SonoSite, Inc. engages in the development, manufacture, and sale of hand-carried ultrasound imaging systems for use in clinical applications and settings. Its products are used for imaging in a variety of medical specialties, such as radiology, obstetrics and gynecology, emergency medicine, surgery, cardiology, internal medicine, and vascular medicine. The company's products include SonoSite 180PLUS system for general ultrasound imaging, SonoHeart ELITE for cardiovascular applications, and the SonoSite TITAN system for general imaging and cardiology applications. Its products also include the iLook 25, an imaging tool designed to provide visual guidance for physicians and nurses while performing vascular access procedures, as well as iLook 15, also an imaging tool designed to provide visual imaging of the chest and abdomen for physicians and nurses while performing other procedures and examinations. In addition, the company offers a selection of accessories, including mobile docking stations, multiple transducer connections, image transfer and management software, printers, VCRs, auxiliary monitors, storage devices, carrying cases, and disposable supplies for its products. SonoSite, Inc. sells its products through direct sales representatives and their managers, independent third-party distributors, and strategic alliances in the United States, the United Kingdom, Germany, France, Spain, Japan, Australia, and Canada. SonoSite was incorporated in 1986 and is headquartered in Bothell, Washington.
BIOMIMETIC THERAPEUTICS INC (BMTI)
BioMimetic Therapeutics, Inc. engages in the development and commercialization of bio-active drug-device combination products for healing musculoskeletal injuries and diseases that include periodontal, orthopedic, spine, and sports injury applications. It primarily engages in the development of the treatment for bone loss associated with advanced periodontal disease, and repair and regeneration of orthopedic tissues, including bone, cartilage, and ligaments or tendons. The company's GEM 21S Growth-factor Enhanced Matrix (GEM) is a synthetic regeneration system that combines a recombinant human platelet-derived growth factor with a synthetic bone matrix called beta-tricalcium phosphate in order to treat periodontal bone defects and gum tissue recession associated with periodontal diseases. It also develops GEM product candidates in the field of orthopedics, including bone, tendon, ligament, and cartilage applications. The company also develops GEM OS1 for the treatment of open fractures; GEM OS2 for the treatment of closed fractures; and other GEM OS product candidates for the areas of the skeletons, such as the vertebral bodies of the spine in osteoporotic individuals that are susceptible to fracture, and where stimulation of new bone formation could have a prophylactic therapeutic benefits. In addition, the company's pre-clinical development products include GEM C and GEM LT, which are used for various sports injuries, including those requiring cartilage, ligament, and tendon repair. Further, it offers GEM ONJ for treating osteonecrosis of the jaws. BioMimetic Therapeutics has a partnership with Luitpold Pharmaceuticals, Inc. for the marketing and distribution of GEM 21S worldwide. The company was founded in 1999. It was formerly known as BioMimetic Pharmaceuticals, Inc. and company changed its name to BioMimetic Therapeutics, Inc. in 2005. BioMimetic Therapeutics is headquartered in Franklin, Tennessee.
Alcon, Inc. engages in the development, manufacture, and marketing of pharmaceuticals, surgical equipment and devices, and consumer eye care products to treat diseases and disorders of the eye. Its pharmaceutical products include a line of products to treat glaucoma; anti-infectives, anti-inflammatories, and combination therapies to treat bacterial, viral, and fungal infections of the eye, as well as to control ocular inflammation; products for the treatment of ocular allergies; and generic ophthalmic products and otic pharmaceuticals. The company offers various surgical products, including surgical procedure packs for cataract, vitreoretinal, and refractive surgeries. The single-use products for cataract procedures include cassettes used in the LEGACY and Infiniti vision systems, a line of viscoelastics to protect delicate tissues of the eye during the procedure, surgical knives, and surgical irrigating solutions. The products for vitreoretinal surgery include Accurus surgical system, which integrates all automated and nonlaser surgical functions, and performs phaco procedures for cataract removal. The laser refractive surgical equipment include LADARWave aberrometer, a wave front device that measures refractive errors of the optical system; LADARVision 4000 excimer laser system to combine an active laser radar eye tracker; and a true small-spot laser beam to deliver to surgeons for the treatment of refractive patients. The company's consumer eye care products consist of a line of contact lens care products, artificial tears, and ocular vitamins. Alcon sells its products through sales representatives and distributors in approximately 180 countries. The company was founded in 1945. Alcon was formerly known as Societe Fromagere Nestle S.A. and changed its name to Alcon Universal S.A. in 1978. Further, it changed its name to Alcon, Inc. in 2001. The company is headquartered in Hunenberg, Switzerland. Alcon, Inc. is a subsidiary of Nestle S.A.
BECTON DICKINSON AND COMPANY (BDX)
Becton, Dickinson and Company engages in the manufacture and sale of medical supplies, devices, laboratory equipment, and diagnostic products worldwide. The company has three segments: Medical, Diagnostics, and Biosciences. The Medical segment offers needles, syringes, and intravenous catheters, including safety-engineered devices for medication delivery; insulin injection devices and blood glucose monitors for the treatment of diabetes; prefillable drug delivery devices to pharmaceutical companies and end-users as drug/device combinations; surgical blades and regional anesthesia needles; critical care monitoring devices; ophthalmic surgery devices; sharps disposal containers; and home healthcare products. The Diagnostics segment provides integrated systems for evacuated blood collection, a line of safety-engineered specimen collection products and systems, plated media, automated blood culturing, molecular testing systems for sexually transmitted diseases, microorganism identification and drug susceptibility systems, and manual testing products. The Biosciences segment includes fluorescence activated cell sorters and analyzers, cell imaging systems, monoclonal antibodies and kits, reagent systems for life sciences research, tools to aid in drug discovery and growth of tissue and cells, and diagnostic assays. It serves healthcare institutions, life science researchers, clinical laboratories, industry, and the general public, primarily through independent sales representatives and independent distribution channels. The company was founded in 1897 and is based in Franklin Lakes, New Jersey.
Osteotech, Inc. engages in processing human bone and connective tissue for transplantation, as well as development, manufacture, and marketing of biologic, biomaterial, and device systems for musculoskeletal surgery. It focuses on spinal, trauma, and total joint revision procedures. The company provides services, and develops, markets, and sells products to the orthopaedic, neurological, oral/maxillofacial, and general surgery markets in the United States and Europe. It offers demineralized bone grafts, structural allografts, and other allografts. The company's demineralized bone matrix and base tissue processing yields various freeze-dried, frozen, and demineralized allograft bone tissue forms that are used by orthopaedic, neurological, plastic, periodontal, and oral/maxillofacial surgeons. Its products are used for spinal fusion procedures; repair and replacement of bone loss caused by trauma or certain disease states; augmentation of prosthetic implant procedures; and replacement of damaged ligaments and tendons. The company processes and develops human bone and bone connective tissue, or allograft bone tissue forms. It also processes, markets, and distributes bovine bone tissue products, which are utilized as bone graft substitutes by surgeons in Europe, Asia, and the Middle East. The company was formed in 1986 and is based in Eatontown, New Jersey.
C. R. Bard, Inc. (Bard) engages in the design, manufacture, packaging, distribution, and sale of medical, surgical, diagnostic, and patient care devices. It has four product groups: Vascular, Urology, Oncology, and Surgical Specialties. In the Vascular products group, the company offers products for the peripheral vascular market. These products include percutaneous transluminal angioplasty catheters, guidewires, introducers and accessories, peripheral stents, vena cava filters, and biopsy devices; electrophysiology products, including diagnostic, therapeutic, and temporary pacing electrode catheters; and fabrics, meshes, and implantable vascular grafts. In the Urology products group, Bard offers foley catheters; surgical sling and injectable tissue bulking products that are used to treat stress urinary incontinence; natural and synthetic materials for the treatment of pelvic floor or vaginal prolapse; brachytherapy services, devices, and radioactive seeds that are used to treat prostate cancer; urine monitoring and collection systems; ureteral stents; and specialty devices for ureteroscopic procedures and stone removal. The company's Oncology products include devices used in the treatment and management of various cancers, and other diseases and disorders. These include specialty access catheters, ports, and enteral feeding devices. Bard's Surgical Specialty products include meshes for hernia and other soft tissue repairs; irrigation devices for orthopedic, laparoscopic, and gynecological procedures; and products for topical hemostasis. It sells its products to hospitals, individual health care professionals, extended care facilities, and alternate site facilities worldwide. Bard distributes its products directly and through distributors. The company was founded in 1907 by Charles Russell Bard and is headquartered in Murray Hill, New Jersey.
DexCom, Inc., a development stage medical device company, focuses on the design and development of continuous glucose monitoring systems for people with diabetes. The company primarily develops two continuous glucose monitoring systems, including a short-term system with a sensor that can be inserted by a patient; and a long-term system with a sensor that can be implanted by a physician. DexCom was incorporated in 1999 and is headquartered in San Diego, California.
HAEMONETICS CORPORATION (HAE)
Haemonetics Corporation engages in the design, manufacture, and marketing of automated systems and single-use disposables for the collection, processing, and surgical salvage of donor and patient blood. The company's systems enable users to collect and process the blood component they target, such as plasma, platelets, or red blood cells. Its products include PCS brand systems, which automate the collection of plasma from donors; MCS, which automate the collection of platelets; ACP that automate the process used to freeze, thaw, and wash red blood cells. The company's surgical blood salvage systems are used during and after surgery to collect a patient's own blood for reinfusion. These systems include Cell Saver brand systems for higher blood loss surgeries and trauma; OrthoPAT brand systems for lower, slower blood loss procedures; and cardioPAT brand system for blood loss during and after beating heart surgeries or for blood loss after various coronary artery bypass graft surgeries. The company offers its products primarily through direct sales force, independent distributors, and agents principally in the United Sates, Europe, and Japan and other parts of Asia. Haemonetics was founded in 1971 and is based in Braintree, Massachusetts.
STRATEGIC DIAGNOSTICS INC (SDIX)
Strategic Diagnostics, Inc. engages in the development, manufacture, and marketing of antibody products and analytical test kits for a range of food, water, agricultural, industrial, environmental, and scientific applications primarily in the United States. It primarily focuses on immunology, proteomics, bio-luminescence, and other bio-reactive technologies. The company offers monoclonal and polyclonal antibody products and services in the areas of hybridoma development, cell culture techniques, large-scale ascites and antisera production, large-scale antibody purification, chemical modification of immunogens and antibodies, and characterization of antibodies and a range of related services. It also manufactures a line of human-serum-based calibrators for serum protein markers. The company's antibody products and services sells its products to pharmaceutical, biotechnology and diagnostic companies, and biomedical research centers under Strategic BioSolutions brand name. Its food safety product line includes enrichment media and rapid tests to detect food pathogens. The company's water quality products include analytical tests for drinking water, industrial process water and wastewater analysis, and analytical tests for soil and other waste matrices for use at environmental remediation projects, hazardous waste operations, and other applications. Strategic Diagnostics markets and sells its products in the food safety, water quality, and life science antibody markets through direct sales force, Internet, and distributors in Canada, Mexico, Latin America, Europe, and Asia. The company was founded in 1987 and is headquartered in Newark, Delaware.
Uroplasty, Inc., a medical device company, engages in the development, manufacture, and marketing of products for the treatment of voiding dysfunctions, including urinary and fecal incontinence, and overactive bladder symptoms. It primarily offers Macroplastique implants, a minimally invasive, implantable soft tissue bulking agent for the treatment of urinary incontinence; PTQ implants for the treatment of fecal incontinence; VOX implants for the treatment of vocal cord rehabilitation; and Bioplastique implants for dermal augmentation. The company also offers Urgent PC neuromodulation system, a device designed for office-based treatment of overactive bladder symptoms of urinary urge incontinence, urinary urgency, and urinary frequency; and I-Stop, a biocompatible, polypropylene, tension-free sling for the treatment of female urinary incontinence. Uroplasty markets its products through direct field sales and independent sales representatives in the United States; and a direct sales organization in the United Kingdom, as well as through distributors in other markets. The company was incorporated in 1992 and is headquartered in Minnetonka, Minnesota.
ALPHATEC HOLDINGS INC (ATEC)
Alphatec Holdings, Inc. engages in the design, development, manufacture, and marketing of products for the surgical treatment of spine disorders. It offers spine screws, spinal spacers, and plates. The company's products include fusion systems that are used to facilitate the growth of a boney connection; lumbar fixation system, a spinal system, which offers fixed angle pedicle screws, polyaxial pedicle screws, and advanced instrument design; spinal fixation system designed to allow the rod to be placed closer to the center of the patient's body; ROC lumbar plating system, a posterior lumbar plating system that provides an alternative to traditional screw and rod constructs; and deformity system. Its product portfolio also comprise tamarack anterior thoracolumbar plating system; trauma/tumor fixation system for use in anterior thoracolumbar fixation for the treatment of tumor, trauma, and anterior deformity; anterior cervical plate system, which consists of fixed hole plates and a locking mechanism that allow screws to be set at variable angles; and reveal anterior cervical plate system that allows the surgeon to visualize the graft site during surgery. In addition, Alphatec offers posterior cervical/thoracic fusion system comprising rods, polyaxial screws, and offset connectors; PEEK and titanium spacers; allograft spacers; Alphagraft product that is used for bone grafting; and Alphagrans product, which are bioabsorbable synthetic granules. Further, the company develops Connect II allograft spacer, minimally invasive system, occipital plate for placement at the base of the skull in posterior fusion procedures, ALIF plate system designed for anterior lumbar interbody fusion, dynamic cervical plate system, and dynamo rod that allows for controlled compression and distraction of vertebrae adjacent. Alphatec sells its products through independent distributors in the United States and Japan. The company was founded in 1990 and is headquartered in Carlsbad, California.
STRYKER CORPORATION (SYK)
Stryker Corporation engages in the development, manufacture, and marketing of orthopedic products and medical specialties worldwide. It operates in two segments, Orthopedic Implants and MedSurg Equipment. The Orthopedic Implants segment sells orthopedic reconstructive, trauma, spine and micro implant systems, bone cement, and the bone growth factor OP-1 products. The MedSurg Equipment segment offers powered surgical instruments, surgical navigation systems, endoscope products, medical video imaging equipment, and hospital beds and stretchers. The company also provides outpatient physical therapy services to its customers that includes physical, occupational, and speech therapy services to patients recovering from orthopedic or neurological illness and injury. Its products are sold in approximately 100 countries through local dealers and direct sales efforts. The company was founded in 1941 and is headquartered in Kalamazoo, Michigan.
MERIT MEDICAL SYSTEMS INC (MMSI)
Merit Medical Systems, Inc. (MMS) engages in the development, manufacture, and marketing of disposable medical products primarily for use in the diagnosis and treatment of cardiovascular disease in the United States. The company's products consist of coronary control syringes; inflation devices and monitors; specialty syringes; high-pressure tubing and connectors; waste management products; disposable blood pressure transducer and pressure monitoring tubing; disposable hemostasis valves and accessories, and guide wire torque devices; manifolds and stopcocks; radial artery compression systems; contrast management systems; angiography needles and accessories; drainage catheters and accessories; pericardiocentesis catheters and procedure trays; thrombolytic infusion catheters and accessories; diagnostic angiographic pigtail catheters, diagnostic cardiology and radiology catheters, and marker band catheters; guide catheters; sheath introducers, vessel dilators, fixed and movable core, diagnostic guide wires and accessories, and hydrophilic guide wires; pressure infusor bags; and procedure trays. It serves hospital-based cardiologists, radiologists, anesthesiologists, physiatrists, neurologists, technicians, and nurses. MMS was founded by Fred P. Lampropoulos and Kent W. Stanger in 1987. The company is headquartered in South Jordan, Utah.
ABIOMED, Inc. engages in the development, manufacture, and marketing of medical products to assist or replace the pumping function of the failing heart. ABIOMED manufactures and sells the AB5000 Circulatory Support System and the BVS 5000 Biventricular Support System for the temporary support of patients with failing but potentially recoverable hearts. BVS and AB5000 are sold in the United States through direct sales and clinical support teams. In Europe, ABIOMED offers the Impella Recover minimally invasive cardiovascular support systems. Its AbioCor, which is in clinical trials, is a heart replacement device for the failing ventricles of a patient's diseased heart and takes over the heart's blood pumping function. ABIOMED conducts its international sales efforts through distributors and by selling directly in selected European markets through ABIOMED B.V., its wholly owned subsidiary. The company was founded by David M. Lederman in 1981. ABIOMED is headquartered in Danvers, Massachusetts.
MESA LABORATORIES INC (MLAB)
Mesa Laboratories, Inc. engages in the design, manufacture, and marketing of electronic instruments and supplies. Its product line consists of recording systems, which are used to measure temperature, humidity, and pressure inside a process or inside a product during manufacturing; fluid measurement components, such as flow meters, used in water treatment, chemical processing, and heating, ventilation, and air conditioning applications; and concentration analyzers and pipeline interface detectors, which are used in chemical, food, pharmaceutical, and polymerization processes. The company also manufactures and distributes electronic measurement systems for renal treatment, including dialysate meters and dialyzer reprocessing products used in kidney dialysis. Mesa Laboratories was incorporated in 1982 and is based in Lakewood, Colorado.
Covidien, Ltd., through its subsidiaries, engages in the development, manufacture, and distribution of medical devices and supplies, diagnostic imaging agents, pharmaceuticals, and other healthcare products for use in clinical and home settings. It has five segments: Medical Devices, Imaging Solutions, Pharmaceutical Products, Medical Supplies, and Retail Products. The Medical Devices segment offers surgical instruments and devices, respiratory and monitoring solutions, and other medical devices. It offers its products to physicians, nurses, materials managers, group purchasing organizations, and governmental healthcare authorities. The Imaging Solutions segment provides contrast agents, contrast delivery systems, and radiopharmaceuticals to physicians, technologists, and purchasing administrators at hospitals, imaging centers, cardiology clinics, and radiopharmacies. The Pharmaceutical Products segment supplies active ingredients used in pharmaceuticals, dosage pharmaceuticals, and specialty chemicals. It sells active pharmaceutical ingredients to branded and generic pharmaceutical manufacturers; and dosage products to wholesalers and drug store chains. The Medical Supplies segment offers traditional wound care products, absorbent hygiene products, and operating room kits and accessories, as well as operates as an original equipment manufacturer of various medical supplies for various medical device companies. Its products are used in hospitals, surgi-centers, and alternate care facilities and are marketed to materials managers and group purchasing organizations. The Retail Products segment provides private label absorbent hygiene products, including private label adult incontinence, feminine hygiene, and infant care products to mass merchandisers, food stores, and drug stores. The company, formerly known as Tyco Healthcare, Ltd., was founded in 1960. It changed its name to Covidien, Ltd. in February 2007. The company is based in Pembroke, Bermuda.
Cardica, Inc. designs and manufactures proprietary automated anastomotic systems used by surgeons to perform coronary artery bypass surgery. The company's products include C-Port Distal Anastomosis System, which is designed to perform an end-to-side distal anastomosis by attaching the end of a bypass vein graft to a coronary artery downstream of an occlusion or narrowing; C-Port xA Distal Anastomosis System, an enhanced C-Port system, which includes a change from a spring-driven to a gas release-driven stapling mechanism, as well as incorporates non-traumatic vessel clamps and safety mechanisms; and C-Port Flex A Anastomosis System, which includes modifications to the C-Port xA system that are designed to enable automated anastomoses to be performed as part of minimally invasive and robot-facilitated CABG procedures. Its products also comprise PAS-Port Proximal Anastomosis System, an automated device used to perform an end-to-side proximal anastomosis between a saphenous vein and the aorta. In addition, the company develops the Cook Vascular Closure Device to be used in interventional vascular procedures. Cardica has an agreement with Cook Incorporated for the development of the Cook Vascular Closure Device, as well as to develop and commercialize a specialized device to close the PFO. It primarily sells the C-Port systems in the United States and Europe, and the PAS-Port systems in Europe and in Japan through distributors. The company was founded in 1997 as Vascular Innovations, Inc. and changed its name to Cardica, Inc. in 2001. Cardica is headquartered in Redwood City, California.
ORASURE TECHNOLOGIES INC (OSUR)
OraSure Technologies, Inc. engages in the development, manufacture, and marketing of oral specimen collection devices. Its products include Q.E.D. Saliva Alcohol Test and Intercept, a laboratory-based oral fluid drug test; OraSure HIV-1 oral fluid specimen device, a collection device that collects oral fluid to test for antibodies to the HIV-1 virus; OraQuick Rapid HIV-1 antibody test, a point-of-care test to aid in the diagnosis of infection to HIV-1 using a fingerstick and venipuncture whole blood specimen; Toxicology kits for use in testing blood, urine, hair, oral fluid, sweat, and other forensic samples. The company also offers enzyme immunoassay test kits and oral fluid collection devices, which are used to perform risk assessment testing of life insurance applicants and screen for drugs of abuse, nicotine use, and therapeutic drugs, to insurance laboratory clients; OraSure, a set of MICRO-PLATE products to the blood fractionation market for testing of plasma and related products; Cryosurgery for treating various superficial benign skin lesions, including warts, actinic keratoses, seborrheic keratoses, skin tags, age spots, condyloma acuminate, and molluscum; and Histofreezer portable cryosurgical system for cryosurgery. The company sells its products in the United States and internationally to various clinical laboratories, hospitals, clinics, community-based organizations and other public health organizations, distributors, government agencies, physicians' offices, and commercial and industrial entities. OraSure Technologies is headquartered in Bethlehem, Pennsylvania.
PerkinElmer, Inc. provides scientific instruments, consumables, and services to the pharmaceutical, biomedical, environmental testing, chemical, and general industrial markets worldwide. It designs, manufactures, markets, and services products and systems in three segments: Life and Analytical Sciences, Optoelectronics, and Fluid Sciences. The Life and Analytical Sciences segment provides drug discovery, genetic screening, and environmental and chemical analysis tools, including instruments, reagents, consumables, and services for daily applications in scientific research and clinical applications. Its products are offered under various brand names, including Wallac, Packard, NEN, AAnalyst, Clarus, OneSource, LABWORKS, Pyris, Spectrum, Optima, DELFIA, ImageTrak, UltraView, prOTOF, Victor, LANCE, ELAN, and ViewLux. The Optoelectronics segment provides digital imaging, sensor, and specialty lighting components used in the biomedical, consumer products, and other specialty end markets under the brand names Cermax, Heimann, ColdBlue, MultiBlue, Power Systems, Amorphous Silicon, and Reticon. The Fluid Sciences segment provides fluid control and containment systems for environments, such as turbine engines and semiconductor fabrication facilities under the brand names Belfab, Callisto, Centurion, U-Plex Seals, E-Seals, Rigid E-Seal Joints, and PressureScience. The company was founded in 1947 and is headquartered in Wellesley, Massachusetts. PerkinElmer, Inc. acquired Elcos AG in February 2005, which designs and manufactures custom light emitting diode and solutions for biomedical and industrial applications.
KENSEY NASH CORPORATION (KNSY)
Kensey Nash Corporation, a medical technology company, engages in the development and manufacture of absorbable biomaterials-based products with applications in the cardiology, orthopaedics, spine, drug and biologics delivery, periodontal/dental, surgical, and wound care markets. It primarily offers Angio-Seal vascular closure device, a device designed to seal and close femoral artery punctures made during diagnostic and therapeutic cardiovascular catheterizations; and TriActiv embolic protection system, a device designed to prevent microparticulate from traveling downstream during the treatment of diseased coronary saphenous vein bypass grafts. This system utilizes active flushing and extraction to remove debris from the vessel after a treatment procedure. The company also develops various bone graft substitutes fabricated from collagen, synthetic polymers, or composite biomaterials. Kensey Nash has a strategic alliance with St. Jude Medical, Inc. The company was founded in 1984 and is based in Exton, Pennsylvania.
Pro-Dex, Inc engages in the design, development, and manufacture of electric, air, and battery powered rotary drive systems for the medical device and dental industries in the United States. Its rotary drive systems are used in the dental, cranial, spinal, arthroscopic, and orthopedic surgery. The company also designs and manufactures pneumatic motors and motion control systems for industrial applications in the automotive, aerospace, apparel, and entertainment industries. In addition, Pro-Dex develops motion control software and hardware for industrial and scientific applications. It also distributes its line of pneumatic and electric dental hand pieces under the brand ‘Micro Motors' in North America. The company's products are used in hospitals, dental offices, medical engineering labs, scientific research facilities, and manufacturing operations. It distributes its products through its sales force and independent sales representatives within North America, as well as distributes through sales agreements with foreign distributors or through the domestic subsidiaries of foreign customers internationally. Pro-Dex was founded in 1978 and is headquartered in Santa Ana, California.
AMDL, Inc., a theranostics company, engages in both the detection and treatment of cancer. It develops, manufactures, markets and sells various immunodiagnostic kits. Its products include DR-70, a test kit that is used in the detection of approximately 13 different types of cancer, including lung, stomach, breast, rectal, colon, and liver; and Pylori-Probe, which is cleared for sale in the United States. The company also offers private label test kits to underserved international markets through distributor relationships and to domestic markets through strategic partnerships and relationships with diagnostic companies. AMDL was incorporated in 1988 and is based in Tustin, California.
INTEGRA LIFESCIENCES HOLDINGS CORPORATION (IART)
Integra LifeSciences Holdings Corporation engages in the development, manufacture, and marketing of medical devices for use in neuro-trauma, neurosurgery, reconstructive surgery, and general surgery. Its product groups include monitoring products, implants, instruments, and private label products. The company's monitoring products include intracranial pressure (ICP) monitoring systems, cerebral blood flow and ICP systems, oxygen monitoring systems, cranial access and cerebrospinal fluid drainage systems, epilepsy monitoring electrodes, and electroencephalogram, evoked potential, and electromyography electrodes, as well as disposables and other supplies. Its implants include absorbable collagen products, skin replacement and engineered wound dressings, hydrocephalus management products, peripheral nerves repair and protection products, hydrocephalus management, small bone and joint fixation devices and instruments, and hemodynamic shunts. The company's instruments include ultrasonic aspirator, cranial stabilization and positioning systems, halo retractor system, electro-surgery generators, neurosurgical and spinal instruments, reconstructive and plastic surgery instruments, harvesting and conditioning skin grafts devices, and spinal specialties. Integra LifeSciences sells its products primarily through catalogs and telemarketing to neurologists, hospitals, sleep clinics, and other physicians. The company also distributes various disposables and supplies, including surface electrodes, needle electrodes, recording transducers and stimulators, and respiratory sensors. Integra LifeSciences Holdings was founded in 1989 and is based in Plainsboro, New Jersey.
I-FLOW CORPORATION (IFLO)
I-Flow Corporation engages in the design, development, manufacture, and marketing of ambulatory infusion systems for pain management and infusion therapy. It manufactures a line of infusion pumps, catheters, and pain kits that administer medication directly to the wound site, as well as administer local anesthetics, chemotherapies, antibiotics, diagnostic agents, nutritional supplements, and other medications. The company sells and distributes its products in the United States, Canada, Europe, Asia, Mexico, Brazil, Australia, New Zealand, and the Middle East. In addition, it engages in the rental of infusion pumps on a month-to-month basis for the treatment of cancer. I-Flow Corp. has a partnership with the University of Minnesota to conduct an animal study to evaluate the promise of antimicrobial benefits of ON-Q. The company was established in 1985 and is headquartered in Lake Forest, California.
THORATEC CORPORATION (THOR)
Thoratec Corporation manufactures circulatory support products for use by patients with congestive heart failure. The company operates in two segments, Cardiovascular and International Technidyne Corporation (ITC). The Cardiovascular segment develops, manufactures, and markets medical devices used for circulatory support products, which include ventricular assist device for the short-term and long-term treatment of congestive heart failure, as well as vascular graft products for use as a shunt between an artery and a vein. It offers a product portfolio of implantable and external circulatory support product devices, including the Thoratec Implantable Ventricular Assist Device, a biventricular implantable blood pump; the HeartMate Left Ventricular Assist System (LVAS), an implantable device for mid to long-term cardiac support for those patients ineligible for heart transplantation; and the HeartMate II, an implantable LVAS consisting of a miniature rotary blood pump that is designed to provide long-term support. These products are sold into the hospital point-of-care (POC) market, and the alternate site POC market comprising physician's offices, long-term care facilities, clinics, visiting nurse associations, and home healthcare companies. ITC segment designs, develops, manufactures, and markets point-of-care diagnostic test systems that monitor a patient while being administered certain anticoagulants, blood gas/electrolyte, and chemistry status or anemia; and incision products to obtain a patient's blood sample for diagnostic testing and screening for platelet function. The company markets its products through direct sales force and distributors in the United States, Canada, France, Germany, Spain, the United Kingdom, Austria, Switzerland, the Netherlands, Portugal, and South Africa. Thoratec Corporation was founded in 1976 and is headquartered in Pleasanton, California.
Orthovita, Inc. engages in the development and marketing of synthetic-based biomaterial products for use in spine surgery, the repair of osteoporotic fractures, and a range of clinical needs in the trauma, joint reconstruction, revision, and extremities markets primarily in the United States. Its products include VITOSS bone graft substitute (VITOSS), IMBIBE bone marrow aspirate syringe (IMBIBE), ENDOSKELETON TA device, CORTOSS synthetic cortical bone void filler (CORTOSS), VITAGEL surgical hemostat, and ALIQUOT microdelivery system. VITOSS is an ultra-porous resorbable beta-tricalcium phosphate bone void filler used to enable the body guide the three-dimensional regeneration of the patient's own bone. The IMBIBE provides spine and orthopedic surgeons with a method for harvesting a patient's bone marrow, mixing it with VITOSS and delivering the mixture to the bone graft site. ENDOSKELETON TA device provides physiological support to, or replaces damaged vertebral bodies. The CORTOSS is a bone-bonding and self-setting composite engineered specifically to mimic the characteristics of human cortical bone. VITAGEL is a composite liquid hemostat that combines the biomaterials thrombin and collagen with the patient's autologous plasma for soft-tissue healing. The ALIQUOT microdelivery system facilitates delivery of the company's CORTOSS product directly to the surgical site. Orthovita also offers VITOMATRIX particulate synthetic scaffold biomaterial and bone graft substitute materials, such as VITOSS FOAM products, which combine VITOSS technology with resorbable biomaterials to produce an array of pliant, flexible, flowable, and compression resistant bone graft materials. In addition, the company distributes products, which compliment its biomaterial platforms. It sells its products through direct sales force, independent sales agency, and stocking distributors. Orthovita was incorporated in 1992 and is headquartered in Malvern, Pennsylvania.
ICU Medical, Inc. engages in the development, manufacture, and marketing of disposable medical connection systems for use in intravenous (I.V.) therapy applications. Its products include CLAVE, a one-piece, needleless I.V. connection device; custom I.V. systems; Punctur-Guard line of blood collection needles; CLC2000, one piece, swabable connector used to connect I.V. lines to catheters; 1o2 Valve, a one-way or two-way drug delivery system; and Lopez Enteral Valve, a small ‘T' valve designed to be connected into nasogastric, gastric, or jejunostomy tube systems. The company's devices are designed to protect healthcare workers and their patients from exposure to infectious diseases, such as Hepatitis B and C and Human Immunodeficiency Virus, through accidental needlesticks. In addition, the company develops a family of single-use needleless connectors for use in piggyback and nonpiggyback applications. ICU Medical sells its products to I.V. product manufacturers and independent distributors. It distributes its products in the United States, Canada, western Europe, the Pacific Rim, Latin America, and South Africa. ICU Medical was founded by George A. Lopez and is based in San Clemente, California.
SenoRX, Inc. engages in the design, development, manufacture, and marketing of devices for the diagnosis and treatment of breast cancer. It offers products for the cancer biopsy, marking, fixation, detection, and excision phases. The company markets interventional breast diagnostic products for the healthcare institutions in the United States and Canada. SenoRx was co-founded by Fred H. Burbank and Paul Lubock in 1998. The company is based in Aliso Viejo, California.
AngioDynamics, Inc. engages in the design, development, manufacture, and marketing of medical devices for the minimally invasive diagnosis and treatment of peripheral vascular disease. Its products include angiographic catheters, hemodialysis catheters, plasma thromboplastin antecedent dilation catheters, thrombolytic products, image-guided vascular access products, endovascular laser venous system products, and drainage products. The company's therapeutic and diagnostic devices enable interventional radiologists, vascular surgeons, and others to treat peripheral vascular diseases and other noncoronary diseases. AngioDynamics sells its products primarily in the United States, Europe, and Japan. The company was co-founded by Eamonn P. Hobbs in 1988. It was formerly known as A.D., Inc. and changed its name to AngioDynamics, Inc. in 1996. AngioDynamics is headquartered in Queensbury, New York.
LEMAITRE VASCULAR INC (LMAT)
LeMaitre Vascular, Inc. engages in the development, manufacture, and marketing of disposable and implantable vascular devices for the treatment of peripheral vascular disease. The company's products include EndoFit Thoracic Stent Graft used for the repair of thoracic aortic aneurysm and dissection; UniFit Abdominal Stent Graft for abdominal aortic aneurysm; VascuTape Radiopaque Tape for the improvement of endovascular procedures; AnastoClip Vessel Closure System for the attachment of blood vessels, primarily for dialysis access; Expandable LeMaitre Valvulotome for destructing vein valves to create vein bypass graft; Pruitt-Inahara and Pruitt F3 Carotid Shunts for the facilitation of blood flow to brain during carotid plaque removal; and InvisiGrip Vein Stripper, a single-incision removal of varicose veins. Its product portfolio also comprise LeMaitre Balloon Catheters for the removal of blood clots, occlusion, and facilitation of blood flow; Reddick Cholangiogram Catheter for the introduction of dye into the cystic duct; and OptiLock Implantable Port, a central venous infusion of drugs and nutrients. The company sells its products to vascular surgeons and interventionalists through direct sales force and a network of distributors in the United States, Canada, and internationally. LeMaitre Vascular was founded in 1983. It was formerly known as Vascutech, Inc. and changed its name to LeMaitre Vascular, Inc. in 2001. The company is headquartered in Burlington, Massachusetts.
NeuroMetrix, Inc., a medical device company, engages in the design, development, and sale of proprietary products used to diagnose neuropathies. Neuropathies are diseases of the peripheral nerves and parts of the spine that frequently are caused by or are associated with diabetes, low back pain, and carpal tunnel syndrome, as well as other clinical disorders. The company offers NC-stat System, a neuropathy diagnostic system that provides physicians the ability to diagnose patients with neuropathies at the point-of-service. The system comprises disposable NC-stat biosensors; the NC-stat monitor and related components; and the NC-stat docking station, an optional device that enables the physician to transmit data to the company's onCall Information System. NeuroMetrix also has products under development, such as devices for the treatment of neuropathy, new NC-stat biosensors and associated software for the medically appropriate testing of additional nerves, and third generation NC-stat monitor and docking station. As of April 27, 2005, the NC-stat System was used in approximately 2,400 physician's offices, clinics, and other health care facilities. The company markets its products through regional sales managers and independent regional sales agencies to physicians in the United States. NEUROMetrix was founded by Shai N. Gozani in 1996 and is headquartered in Waltham, Massachusetts.
Daxor Corporation operates as a medical device manufacturing and biotechnology company in the United States. It is developing BVA-100, which measures human blood volume. This instrument is used in conjunction with a single use radiopharmaceutical diagnostic injection kit known as Volumex. BVA-100 has an accuracy of approximately 98% while also providing the predicted normal blood volume for that specific individual based on the height, weight, and sex of the patient. Daxor's patented Volumex utilizes Albumin I-131, a classic tracer used for blood volume measurement. The company, through its wholly owned subsidiary, Scientific Medical Systems, operates a frozen blood bank in New York that allows people to store their own blood utilizing cryobiology technology for approximately 10 years. In addition, Idant, a division of the Scientific Medical subsidiary, provides sperm banking services. The company also provides special screening for rare hereditary recessive genetic traits. Daxor was founded in 1970 and is based in New York City.
WEST PHARMACEUTICAL SERVICES INC (WST)
West Pharmaceutical Services, Inc. engages in the development, manufacture, and sale of components and systems used for injectable drug delivery worldwide. Its components include elastomeric stoppers and aluminum seals for vials, multipiece tamper-resistant plastic, and aluminum closures; and components used in syringe, intravenous, and blood collection systems. It also provides plastic systems and components for use in over the counter drugs, personal care, and food and beverage applications. The company provides components and/or contract services to pharmaceutical, biotechnology, and hospital supply/medical device companies. It distributes its products and services primarily through its own sales force and regional distributors. The company supports its partners and customers from 50 locations in North America, South America, Europe, Mexico, Japan, Asia, and Australia. West Pharmaceutical was founded in 1923 and is headquartered in Lionville, Pennsylvania.
UTAH MEDICAL PRODUCTS INC (UTMD)
Utah Medical Products, Inc. (UMP) engages in the development, manufacture, assembling, and marketing of disposable and reusable specialty medical devices. It offers medical devices used in critical care areas, especially the neonatal intensive care unit, and the labor and delivery department in hospitals, as well as products sold to outpatient clinics and physician's offices. The company's obstetrics products include fetal monitoring accessories, vacuum-assisted delivery systems, and other obstetrical tools. Its neonatal intensive care products include the DISPOSA-HOOD, an infant respiratory hood; DELTRAN PLUS, a blood pressure monitoring system; and umbilical vessel catheters. The company's other specialty products include a disposable peritoneal dialysis set, a silicone oral protection device used to prevent palatal soft tissue injury by orotracheal tubes, and a lumbar sampling kit for obtaining cerebral spinal fluid samples. UMP's gynecology/urology/and electro surgery products consists of the LETZ System that is used to excise cervical intraepithelial neoplasia and other lower genital tract lesions related to human papilloma virus infections; FINESSE electrosurgical system and specialized electrodes; EPITOME, an electrosurgical scalpel; LIBERTY System to treat urinary incontinence in women; PATHFINDER PLUS, an endoscopic irrigation device; ENDOCURETTE for uterine endometrial tissue sampling; and LUMIN for manipulation of the uterus in gynecological laparoscopic procedures. Its blood pressure monitoring line comprises DELTRAN disposable pressure transducer; and pressure monitoring accessories, components, and other molded parts. The company sells its products through direct sales representatives and independent manufacturers' representatives in the United States, as well as through specialty distributors, other medical device companies, and independent medical products distributors internationally. UMP was formed in 1978 and is headquartered in Midvale, Utah.
CARDIAC SCIENCE CORPORATION (CSCX)
Cardiac Science Corporation engages in the development, manufacture, and marketing of diagnostic and therapeutic cardiology products and services in the United States and internationally. Its products include automated external defibrillators; electrocardiographs that allow physicians to record and analyze patient ECG waveforms; cardiac stress testing systems, which enable cardiologists and other healthcare providers to monitor and analyze the performance of the heart under stress; Holter monitoring systems, which record the patient's heart rate, heart rhythm, and electrocardiograph waveform data during various activities; and cardiac rehabilitation telemetry systems that enable cardiologists and other healthcare providers to track and assess improvements in cardiovascular function. The company's products also comprise cardiology data management systems that automate the processing, storage, retrieval, and editing of electrocardiographic data. In addition, it supplies lead wires and electrodes used in the retrieval and processing of patient ECGs; thermal chart paper to generate reports; and a line of other complementary cardiology-related products, such as blood pressure monitors and spirometers. The company markets its products under the Burdick, Powerheart, and Quinton brand names. Cardiac Science Corporation was founded in 1953 and is headquartered in Bothell, Washington.
CANTEL MEDICAL CORP (CMN)
Cantel Medical Corp. provides infection prevention and control products for the healthcare market. Its Dialysis segment includes disinfection/sterilization reprocessing equipment, sterilants, supplies, and concentrates for hemodialysis treatment of patients with acute kidney failure or chronic kidney failure, as well as offers technical maintenance services. The company's Dental segment comprises single-use infection control products used in the dental market, such as face masks, patient towels and bibs, self-sealing sterilization pouches, tray covers, sterilization packaging accessories, surface barriers, disinfectants and deodorizers, germicidal wipes, hand care products, gloves, sponges, cotton products, cups, needles and syringes, scalpels and blades, and saliva evacuators and ejectors. Its Endoscopy and Surgical segment includes diagnostic and therapeutic medical equipment, such as endoscopes, surgical equipment, and related accessories. The company's Endoscope Reprocessing segment consists of endoscope disinfection equipment, and related accessories and supplies. Its Water Purification and Filtration segment includes water purification equipment design and manufacturing, project management, installation, maintenance, deionization, and mixing systems, as well as hollow fiber filter devices and ancillary products for fluid and separation applications for the medical, pharmaceutical, biotechnology, research, beverage, and semiconductor industries. In addition, the company offers microscopes, image analysis hardware and related accessories; and industrial technology equipment, such as borescopes, fiberscopes, and video image scopes. It also offers specialized packaging for the safe transport of infectious and biological specimens, and compliance training services. Cantel Medical has operations in Singapore, Taiwan, China, the Netherlands, the United Kingdom, and the United States. The company was founded in 1963 and is based in Little Falls, New Jersey.
BIOSPHERE MEDICAL INC (BSMD)
Biosphere Medical, Inc. operates as a medical device company. It engages in the development, manufacture, and marketing of minimally invasive diagnostic and therapeutic applications based on proprietary bioengineered microsphere technology to treat uterine fibroids, hypervascularized tumors, and vascular malformations. The company's products include Embosphere Microspheres, EmboGold Microspheres, Hepasphere SAP Microspheres, EmboCath Hydrophilic Infusion Catheter, and Segway Hydrophilic Guidewire. Embosphere Microspheres and EmboGold Microspheres are used for the treatment of hypervascularized tumors and arteriovenous malformations. Hepasphere SAP Microspheres are used for treatment of liver cancer. EmboCath Hydrophilic Infusion Catheter and Segway Hydrophilic Guidewire are used in peripheral embolization procedures. BioSphere Medical sells its products primarily in the United States and the European Union, as well as in Canada, Middle East, Africa, South America, and Asia. The company was incorporated in 1993. It was formerly known as BioSepra, Inc. and changed its name to BioSphere Medical, Inc. in 1999. BioSphere Medical is headquartered in Rockland, Massachusetts.
ELECTRO-OPTICAL SCIENCES INC (MELA)
Electro-Optical Sciences, Inc., a medical device company, designs and develops a non invasive, hand-held imaging, and point-of-care instrument to assist in the early detection of melanoma in the United States. Its principal product, MelaFind, features a hand-held imaging device that emits light of multiple wavelengths to capture images of suspicious pigmented skin lesions and extract data. The data is then analyzed through its proprietary database of melanomas and benign lesions to provide information to the physician and produce a recommendation of whether the lesion should be biopsied. The company offers its product primarily for general dermatologists, plastic surgeons, and primary care physicians. Electro-Optical Sciences was founded in 1989 and is based in Irvington, New York.
COOPER COMPANIES INC (COO)
The Cooper Companies, Inc. engages in the development, manufacture, and marketing of healthcare products worldwide. It operates in two segments, CooperVision and CooperSurgical. The CooperVision segment develops, manufactures, and markets a range of contact lenses for the vision care market. It specializes in toric lenses that correct astigmatism; cosmetic lenses, which change the appearance of the color of the eye; and other lenses. The CooperSurgical segment engages in the development, manufacture, and marketing of medical devices, diagnostic products, and surgical instruments and accessories, which are used primarily by gynecologists and obstetricians. The company markets its products through field sales representatives and distributors in the United States, Canada, the United Kingdom, Brazil, Portugal, Italy, Spain, France, Holland, Sweden, Norway, Australia, and South Africa. The company was organized in 1980 and is based in Pleasanton, California. The Cooper Companies, Inc. acquired Ocular Sciences, Inc., a contact lens manufacturer, in January 2005.
HOME DIAGNOSTICS INC (HDIX)
Home Diagnostics, Inc. develops, manufactures, and markets blood glucose monitoring systems and disposable supplies for people with diabetics worldwide. It offers blood glucose systems based on biosensor and photometric technology platforms. The biosensor meter technology measures glucose by using an amperometry method employing a glucose oxidase reaction. The photometric meter technology measures blood glucose by using membrane technology that employs a glucose oxidase/peroxidase reaction. The company markets its blood glucose monitoring systems products under Sidekick, TrueTrack Smart System, and Prestige IQ brands, as well as under a co-branded format. In addition, Home Diagnostics provides monitoring accessories, such as disease management software, which allows people with diabetes to record the results of their blood glucose tests and use tools to help identify ways in which they can manage consistent blood glucose levels; Gentle Draw lancing device that enables people with diabetes to obtain a blood sample for a blood glucose test; single-use sterile lancets; and disposable urinary test strips, which are used to test ketone levels in urine. The company sells its products through food and drug retailers, mass merchandisers, distributors, mail service providers, and third-party payors. Home Diagnostics was founded in 1985 and is based in Fort Lauderdale, Florida.
Conceptus, Inc. engages in the development, manufacture, and marketing of medical products for women's health in the United States. The company offers Essure, a permanent birth control device for women that provides a nonincisional alternative to tubal ligation. It markets its product primarily in Australia, Canada, Europe, Indonesia, Singapore, and the United States. Conceptus was founded in 1992 and is headquartered in San Carlos, California.
YOUNG INNOVATIONS INC (YDNT)
Young Innovations, Inc. engages in the development, manufacture, and marketing of supplies and equipment used to enable the practice of dentistry and to promote oral health. Its products include disposable and metal prophylaxis angles, prophylaxis cups and brushes, X-ray machines, moisture control products, infection control products, dental handpieces (drills) and related components, endodontic systems, orthodontic toothbrushes, flavored examination gloves, children's toothbrushes, and children's toothpastes, as well as ultrasonic systems and obturation products used in endodontic surgeries, such as root canal procedures. The company markets its products to dentists, endodontists, orthodontists, dental hygienists, and dental assistants primarily through a network of nonexclusive relationships with dental product distributors. In addition, Young Innovations sells directly to dental and dental hygiene schools, Veterans Administration healthcare facilities, and the U.S. military bases. It offers its products in North America, Europe, South America, Central America, and the Pacific Rim. The company was incorporated in 1995. It was formerly known as Young Dental and changed its name to Young Innovations, Inc. in 1995. Young Innovations is headquartered in Earth City, Missouri.
BOSTON SCIENTIFIC CORPORATION (BSX)
Boston Scientific Corporation engages in the development, manufacture, and marketing of medical devices that are used in interventional medical specialties. The company's products are offered by two groups, Cardiovascular and Endosurgery. The Cardiovascular organization provides products and technologies for use in interventional cardiology, peripheral interventions, vascular surgery, electrophysiology, and neurovascular procedures. The Endosurgery organization provides products and technologies for use in oncology, endoscopy, urology, and gynecology procedures. In addition, the company operates in the neuromodulation market. It provides products for the treatment of auditory disorders and chronic pain. The company's less-invasive medical products are used for enlarging narrowed blood vessels to prevent heart attack and stroke; clearing passages blocked by plaque to restore blood flow; opening obstructions and bringing relief to patients suffering from various forms of cancer; performing biopsies and intravascular ultrasounds; mapping electrical problems in the heart; placing filters to prevent blood clots from reaching the lungs, heart, or brain; treating urological, renal, pulmonary, neurovascular, and gastrointestinal diseases; and modulating nerve activity to treat deafness and chronic pain. The company markets its products through direct sales force, and a network of distributors and dealers. Boston Scientific Corp. has a collaboration agreement with Affinergy, Inc. to investigate new coatings for cardiovascular stents. The company was founded by John E. Abele and Peter M. Nicholas in 1979. Boston Scientific Corp. is headquartered in Natick, Massachusetts.
ANGEION CORPORATION (ANGN)
Angeion Corporation, through its subsidiary, Medical Graphics Corporation, engages in the development, manufacture, and marketing of noninvasive cardio-respiratory diagnostic systems used in the management and improvement of cardio-respiratory health. The company offers its products to health care professionals for the prevention, detection, and treatment of heart and lung disease. Its MedGraphics products include pulmonary function and cardiopulmonary exercise testing systems that operate with its proprietary BreezeSuite Windows2000/XP software to address the needs of hospitals, clinics, and physician offices. Angeion's pulmonary function systems consist of spirometry, pulmonary function systems, and body plethysmograph systems. In addition, it provides cardiopulmonary exercise testing systems, which measure functional capacity, fitness, or conditioning levels, as well as enable physicians to diagnose heart and lung diseases. Further, the company offers cycle ergometers and treadmills for use in diagnostic, rehabilitation, training, and sports medicine applications. Angeion markets its products in the United States through direct sales force, as well as through independent distributors internationally. It also sells health and fitness products through health and fitness clubs, personal training studios, weight loss centers, and other retail outlets. The company was founded in 1992 and is headquartered in Saint Paul, Minnesota.
Vasogen, Inc., a development stage company, engages in the research and development of immune modulation therapies for chronic inflammation underlying cardiovascular disorders primarily in Canada. Its primary product, Celacade, is in two pivotal phase III clinical trials for the treatment of chronic heart failure and peripheral arterial disease. The company's another product VP025 is in preclinical development for the treatment of neurodegenerative disorders, including Parkinson's and Alzheimer's disease. Vasogen was founded in 1980 and is headquartered in Mississauga, Canada.
ROCHESTER MEDICAL CORPORATION (ROCM)
Rochester Medical Corporation engages in the development, manufacture, and marketing of various latex-free and PVC free urinary continence, and urine drainage care products for the home care, extended care, and acute care markets. The company's extended care products include a line of male external catheters for managing male urinary incontinence and a line of intermittent catheters for managing both male and female urinary retention. The extended care products also include the FemSoft Insert, a soft, liquid-filled, and conformable urethral insert for managing female stress urinary incontinence in adult females; and Personal Catheters, a line of disposable intermittent catheters manufactured from silicone for male, female, and pediatric use and in multiple diameters. Its acute care products include a line of standard Foley catheters; and Release-NF Catheter, an antibacterial Foley catheter that reduces the incidence of hospital acquired urinary tract infection. The company also offers standard silicone Foley catheters in a two-lumen version for urinary drainage management and in a three-lumen version that also supports irrigation of the urinary tract. In addition, it manufactures and sells male external catheters made from proprietary nonlatex, nonsilicone material to certain private label customers. The company markets its products through a direct sales force in the United States and independent distributors in international markets. Rochester Medical Corporation was founded in 1988 and is based in Stewartville, Minnesota.
Endologix, Inc. engages in the development, manufacture, sale, and marketing of minimally invasive therapies for the treatment of vascular disease. Its primary focus is the development of the PowerLink System, a catheter-based alternative treatment to surgery for abdominal aortic aneurysms. This system consists of a self-expanding stainless steel stent cage covered with ePTFE, a common surgical graft material. The PowerLink endoluminal graft is implanted in the abdominal aorta, which is accessed through the femoral artery. The implantation causes the blood flow to be shunted away from the weakened or ‘aneurysmal' section of the aorta resulting in the reduction of pressure and potential for the aorta to rupture. The company sells its products to its customers located in North America, Europe, Asia, and Latin America. Endologix is based in Irvine, California.
RETRACTABLE TECHNOLOGIES INC (RVP)
Retractable Technologies, Inc. engages in the design, development, manufacture, and marketing of safety needle devices for the healthcare industry. It offers VanishPoint automated retraction safety syringes and blood collection devices, which eliminate health care worker exposure to accidental needlestick injuries. The company's products also include a dental syringe, a butterfly IV, a self retracting IV catheter introducer, and an auto-disable syringe. Its products are sold to and used by healthcare providers, which include acute care hospitals, alternate care facilities, doctors' offices, clinics, emergency centers, surgical centers, convalescent hospitals, veterans administration facilities, military organizations, public health facilities, and prisons. Retractable Technologies distributes its products through general line, specialty, and international distributors throughout the United States and its territories. Retractable Technologies was founded by Thomas J. Shaw. The company was incorporated in 1994 and is headquartered in Little Elm, Texas.
XTENT, Inc., a medical device company, focuses on the development and commercialization of drug eluting stent systems for the treatment of coronary artery disease. Its drug eluting stent systems are designed to enable physicians to customize length and diameter of the stent at the site of the diseased section of the artery or lesion. The company's stent systems include Custom NX 36, which is used to treat single or multiple lesions; and Custom NX 60 that is used to treat one long lesion or multiple smaller lesions with the use of one device. It is also developing 36mm and 60mm stent systems based on its proprietary technology platform. The company was founded in 2002 and is based in Menlo Park, California.
VASCULAR SOLUTIONS INC (VASC)
Vascular Solutions, Inc., a medical device company, develops solutions to interventional cardiologists and radiologists. Its products include D-Stat Dry hemostatic bandage, a topical pad with a bandage used to control surface bleeding; Pronto extraction catheter, a mechanical system for the removal of soft thrombus from arteries; Vari-Lase endovenous laser, a laser and procedure kit used for the treatment of varicose veins; and Duett sealing device, which is used to seal the puncture site following catheterization procedures. The company also offers D-Stat Flowable hemostat, a mixture used to control bleeding; Langston dual lumen pigtail catheter that is used to measure intravascular pressure gradients; MAX-Support abdominal retraction belt, which is used to allow femoral access in obese patients, and Acolysis ultrasound, a treatment for peripheral occlusive arterial disease. Vascular Solutions offers its products to the physician in the United States and internationally through its direct domestic sales force and international distribution network. The company was founded by Howard Root. Vascular Solutions was incorporated in 1996 and is based in Minneapolis, Minnesota.
BIOLASE TECHNOLOGY INC (BLTI)
Biolase Technology, Inc., a medical technology company, engages in the design, manufacture, and marketing of advanced dental, cosmetic, and surgical lasers and related products primarily in the United States and internationally. Its products include dental laser systems that allow dentists, periodontists, endodontists, oral surgeons, and other specialists to perform various dental procedures, including cosmetic and surgical applications. The company's laser system products include Waterlase system and Diode system. The Waterlase system uses a patented combination of water and laser to perform dental procedures performed using dental drills, scalpels, and other dental instruments for cutting soft and hard tissue. The Diode laser system uses a semiconductor diode laser to perform soft tissue and cosmetic procedures, including tooth whitening. In addition, the company manufactures and sells accessories and disposables for its laser systems, such as hand pieces, laser tips, and tooth whitening gelkits. Biolase Technology sells its products through its direct sales force and a network of independent distributors. The company was founded in 1984 and is headquartered in San Clemente, California.
NMT Medical, Inc. engages in designing, developing, and marketing proprietary implant technologies that allow cardiologists to treat cardiac sources of migraine headaches, stroke, and other brain attacks through minimally invasive, catheter-based procedures. The company designs and develops implants that seal the patent foramen ovale defect. It also offers cardiac septal repair implants delivered with nonsurgical catheter techniques. The company manufactures CardioSEAL, a cardiac septal repair implant; and STARFlex, which incorporates a self-centering system that enables the implant to self-adjust to variations in the anatomy of a septal defect without deforming the septum or interfering with heart valve function. NMT Medical markets CardioSEAL through its direct sales force to customers in the United States and Canada, and markets CardioSEAL and STARFlex directly and through distributors in Europe. In addition, the company sells third party products for use with the CardioSEAL and STARFlex implant devices, principally vascular sizing balloons and sheaths. NMT Medical was co-founded by Morris Simon in 1986 and is headquartered in Boston, Massachusetts.
ev3, Inc., a medical device company, focuses on endovascular technologies for the minimally invasive treatment of vascular diseases and disorders. It operates in two segments, Cardio Peripheral and Neurovascular. The Cardio Peripheral segment includes cardiovascular products, which are used to treat coronary artery disease, atrial fibrillation, and other disorders in heart; and peripheral vascular products, which are used to treat vascular disease in legs, kidney, neck, and various other vascular diseases other than in the brain or the heart. Its peripheral vascular product line consists of peripheral stents, embolic protection devices, a carotid stenting system, thrombectomy devices, balloon angioplasty catheters, foreign object retrieval devices, and guidewires. This segment's cardiovascular product line includes embolic protection devices, thrombectomy devices, and stroke reduction devices, as well as Percutaneous Left Atrial Appendage Transcatheter Occlusion device designed to reduce the risk of stroke in patients with atrial fibrillation. The Neurovascular segment includes products that are used to treat vascular disease and disorders in the brain, including aneurysms and arterial-venous malformations. Its product portfolio comprises embolic coils; liquid embolics; and a range of neurovascular access and delivery products, such as microcatheters, occlusion balloon systems, and guidewires. The company's customers include cardiologists, radiologists, neuro-radiologists, vascular surgeons, neurosurgeons, and other endovascular specialists. ev3 markets its products in the United States, Europe, Canada, and Japan through a direct sales force, and through distributors in other international markets. The company is headquartered in Plymouth, Minnesota.
OCULUS INNOVATIVE SCIENCES INC (OCLS)
Oculus Innovative Sciences, Inc., together with its subsidiaries, engages in the development, manufacture, and marketing of various products to prevent and treat infection in acute and chronic wounds. The company's platform technology includes Microcyn, a proprietary oxychlorine small molecule formulation designed to treat a range of organisms that cause disease or pathogens, including viruses, fungi, spores, and antibiotic resistant strains of bacteria, such as Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus in wounds. It offers Microcyn under its 510(k) clearances in the United States primarily through Website, a national distributor, and regional distributors. The company was incorporated in 1999 as Micromed Laboratories, Inc. and changed its name to Oculus Innovative Sciences, Inc. in 2001. Oculus Innovative is based in Petaluma, California.
INX, Inc. and its subsidiaries provide Internet protocol (IP) telephony and other network infrastructure, and related implementation and support services. Its activities include sale and support of IP communications solutions, IP communications network infrastructure, proprietary call center computer-telephony software, and centralized management of remote-enabled computer networks and helpdesks. The company's IP telephony and network solutions include design, implementation, and support of IP telephony, local area network and wide area network routing and switching, virtual private networks, voice over IP, network security, and wireless networks. It sells these solutions primarily to governmental and educational customers. INX also offers computer telephony products, such as outbound predictive dialing, inbound automatic call distribution, call blending between inbound and outbound activity, voice mail and auto attendant applications, text-to-speech capabilities, Web-based text chatting, fax on demand, interactive voice response, application development and scripting, and support for IP telephony telephone lines. In addition, it offers remote information technology management solutions, which include remote end user and server management, data and network management, and security and Internet services; provides onsite and carry-in computer repair, application support, operating system and network migration services, outsourced IT helpdesk solutions, technical staff augmentation for IT helpdesk operations, and helpdesk solutions consulting services. INX distributes its products and services primarily through sales personnel and resellers. The company was founded by James H. Long in 1983. It was formerly known as Allstar Systems, Inc. and changed its name to I-Sector Corporation in 2000. Further, the company changed its name to INX, Inc. in January 2006. INX is headquartered in Houston, Texas.
NUCRYST PHARMACEUTICALS CORP (NCST)
NUCRYST Pharmaceuticals Corp. develops, manufactures, and commercializes medical products that fight infection and inflammation using its patented atomically disordered nanocrystalline silver technology. It produces nanocrystalline silver as a coating for wound dressing products under the trademark ‘SILCRYST' and as a powder for use as an active pharmaceutical ingredient, which is known as NPI 32101. The company licenses its technology to Smith & Nephew plc, which markets, distributes, and sells products using the company's SILCRYST coatings. These products include Acticoat 3/Acticoat Burn Dressings; Acticoat 7 Dressings; Acticoat Absorbent Dressings; and Acticoat and Moisture Control Dressings. NUCRYST Pharmaceuticals' products are used by hospitals, clinics, burn centers, doctors, offices, home healthcare agencies, and nursing homes for the treatment of various wound types, such as chronic wounds, serious burns, and traumatic and surgical wounds. It also focuses on developing pharmaceutical products containing its NPI 32101 silver to extend the company's nanocrystalline silver technology to the treatment of gastrointestinal conditions. In addition, the company develops a topical cream containing NPI 32101 as a barrier to infection; and involves in the research of potential pharmaceutical products containing NPI 32101 for use in the treatment of gastrointestinal disorders. NUCRYST Pharmaceuticals was founded in 1997 and is headquartered in Wakefield, Massachusetts. NUCRYST Pharmaceuticals Corp. is a subsidiary of The Westaim Corporation.
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